Author Archive for Marco

Could Cancer Research Improve the Treatment of Widespread pain in Fibromyalgia and ME/CFS?

Peripheral Neuropathy in Cancer and Fibromyalgia Billions of dollars are spent annually worldwide on improving the prevention, detection and treatment of cancer. New drugs and treatment modalities are extending survival rates, with recent initial trials even inciting (probably prematurely) speculation Read more [...]

Neuroinflammation: Putting the ‘itis’ back into Myalgic Encephalomyelitis – Back to the Future For Chronic Fatigue Syndrome?

“Our results provide evidence of neuroinflammation in CFS/ME patients, as well as evidence of the possible contribution of neuroinflammation to the pathophysiology of CFS/ME.“ 'Show Me the Inflammation!' It’s perhaps emblematic of a complex and difficult to nail down illness such as ME/CFS Read more [...]

The Energy Disorders: Diabetes, ME/CFS and FM – Can Diabetes Tell Us Anything About Chronic Fatigue Syndrome and Fibromyalgia?

  Small Fiber Neuropathy In the last year or so we've seen four studies published (1,2,3,4) that have found objective evidence of small fiber polyneuropathy in FM patients suggesting that the 'central sensitization' theory of FM may be at best incomplete. In fact peripheral nerve damage may be driving Read more [...]

From Chronic Regional Pain Syndrome to Fibromyalgia to ME/CFS? The ‘Spreading Neuroinflammation’ Model

Complex Regional Pain Syndrome and Spreading neuroinflammation and autoimmunity – a model for ME/CFS and fibromyalgia? Neuroinflammation in ME/CFS and Fibromyalgia In previous articles I've been trying to set out, at some length and based on converging evidence, a proposed model of ME/CFS and a Read more [...]

Sensory Overload: Study Suggests Brains in Fibromyalgia Are Being Pummeled With Too Much Information

New study provides further evidence that problems with sensory gating may contribute to fibromyalgia pain and other symptoms. It’s a Jungle Out There The key to survival in the animal world is to be able to detect threats in the environment and react appropriately.  From the simplest sea Read more [...]

Japanese Sensory Gating Study Reveals Profound Cognitive Deficits Present in Chronic Fatigue Syndrome

SENSORY GATING PART V – VALIDATION? A - Sensory Gating Deficits and Neuroinflammation in ME/CFS – A Testable Hypothesis Part I – Sensory Gating - Set out a hypothesis that, if tested, ME/CFS patients (in particular those patients that would describe themselves as the 'Wired and Tired' Read more [...]

Cooling the Flames: Possible Approaches to Reducing Neuroinflammation in Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia

RESEARCH AVENUES/POTENTIAL TREATMENTS (Please note I have no medical background am in no way qualified to recommend any particular course of treatment for ME/CFS.  The following is a theoretical discussion that logically flows from the proposed neuroinflammatory hypothesis and is intended to outline Read more [...]

The Immune in Neuroimmune: Cytokines, Bugs and NK Cells – Part IV of the Neuroinflammatory Series Continues

(We're in the windup phase of Marco's Neuroinflammatory Series as he explores the role the immune system and pathogens  play in producing the neuroinflammatory state that may underlie chronic fatigue syndrome (ME/CFS) For more on Marco's Neuroinflammatory Series on ME/CFS C - IMMUNE FINDINGS, Read more [...]
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