Complex Regional Pain Syndrome and Spreading neuroinflammation and autoimmunity – a model for ME/CFS and fibromyalgia?
Neuroinflammation in ME/CFS and Fibromyalgia
In previous articles I've been trying to set out, at some length and based on converging evidence, a proposed model of ME/CFS and a Read more [...]
New study provides further evidence that problems with sensory gating may contribute to fibromyalgia pain and other symptoms.
It’s a Jungle Out There
The key to survival in the animal world is to be able to detect threats in the environment and react appropriately. From the simplest sea Read more [...]
SENSORY GATING PART V – VALIDATION?
A - Sensory Gating Deficits and Neuroinflammation in ME/CFS – A Testable Hypothesis
Part I – Sensory Gating - Set out a hypothesis that, if tested, ME/CFS patients (in particular those patients that would describe themselves as the 'Wired and Tired' Read more [...]
RESEARCH AVENUES/POTENTIAL TREATMENTS
(Please note I have no medical background am in no way qualified to recommend any particular course of treatment for ME/CFS. The following is a theoretical discussion that logically flows from the proposed neuroinflammatory hypothesis and is intended to outline Read more [...]
(We're in the windup phase of Marco's Neuroinflammatory Series as he explores the role the immune system and pathogens play in producing the neuroinflammatory state that may underlie chronic fatigue syndrome (ME/CFS)
For more on Marco's Neuroinflammatory Series on ME/CFS
C - IMMUNE FINDINGS, Read more [...]
NEUROINFLAMMATORY MODEL OF ME/CFS Part IV – SYMPTOMS, HETEROGENEITY AND ONSET -PULLING IT ALL TOGETHER?
B - CAN THE NEUROINFLAMMATORY STATE EXPLAIN THE CARDINAL SYMPTOMS OF ME/CFS? - SYMPTOMS - FROM MOOD DISORDERS TO TINNITUS
Firstly, it must be acknowledged that this line of inquiry started Read more [...]
A – A PERSONAL PERSPECTIVE ON 'ME/CFS'
I want to make a controversial and potentially unpopular proposal: that ME/CFS is not a discrete disease in any objective sense and that attempting to more rigorously define a 'pure' ME/CFS cohort is futile.
In Parts I to III, I set out what I suggest Read more [...]
(Marco digs into a controversial subject in this second of two blogs on Stiff Person Syndrome and ME/CFS - "Is the depression/anxiety present in Stiff Person Syndrome and, possibly by reflection, chronic fatigue syndrome (ME/CFS), a consequence of having a difficult disease or is it an inherent Read more [...]