Small Fiber Neuropathy
In the last year or so we've seen four studies published (1,2,3,4) that have found objective evidence of small fiber polyneuropathy in FM patients suggesting that the 'central sensitization' theory of FM may be at best incomplete. In fact peripheral nerve damage may be driving Read more [...]
Complex Regional Pain Syndrome and Spreading neuroinflammation and autoimmunity – a model for ME/CFS and fibromyalgia?
Neuroinflammation in ME/CFS and Fibromyalgia
In previous articles I've been trying to set out, at some length and based on converging evidence, a proposed model of ME/CFS and a Read more [...]
New study provides further evidence that problems with sensory gating may contribute to fibromyalgia pain and other symptoms.
It’s a Jungle Out There
The key to survival in the animal world is to be able to detect threats in the environment and react appropriately. From the simplest sea Read more [...]
SENSORY GATING PART V – VALIDATION?
A - Sensory Gating Deficits and Neuroinflammation in ME/CFS – A Testable Hypothesis
Part I – Sensory Gating - Set out a hypothesis that, if tested, ME/CFS patients (in particular those patients that would describe themselves as the 'Wired and Tired' Read more [...]
RESEARCH AVENUES/POTENTIAL TREATMENTS
(Please note I have no medical background am in no way qualified to recommend any particular course of treatment for ME/CFS. The following is a theoretical discussion that logically flows from the proposed neuroinflammatory hypothesis and is intended to outline Read more [...]
(We're in the windup phase of Marco's Neuroinflammatory Series as he explores the role the immune system and pathogens play in producing the neuroinflammatory state that may underlie chronic fatigue syndrome (ME/CFS)
For more on Marco's Neuroinflammatory Series on ME/CFS
C - IMMUNE FINDINGS, Read more [...]
NEUROINFLAMMATORY MODEL OF ME/CFS Part IV – SYMPTOMS, HETEROGENEITY AND ONSET -PULLING IT ALL TOGETHER?
B - CAN THE NEUROINFLAMMATORY STATE EXPLAIN THE CARDINAL SYMPTOMS OF ME/CFS? - SYMPTOMS - FROM MOOD DISORDERS TO TINNITUS
Firstly, it must be acknowledged that this line of inquiry started Read more [...]
A – A PERSONAL PERSPECTIVE ON 'ME/CFS'
I want to make a controversial and potentially unpopular proposal: that ME/CFS is not a discrete disease in any objective sense and that attempting to more rigorously define a 'pure' ME/CFS cohort is futile.
In Parts I to III, I set out what I suggest Read more [...]