NEUROINFLAMMATORY MODEL OF ME/CFS Part IV – SYMPTOMS, HETEROGENEITY AND ONSET -PULLING IT ALL TOGETHER?
B - CAN THE NEUROINFLAMMATORY STATE EXPLAIN THE CARDINAL SYMPTOMS OF ME/CFS? - SYMPTOMS - FROM MOOD DISORDERS TO TINNITUS
Firstly, it must be acknowledged that this line of inquiry started Read more [...]
A – A PERSONAL PERSPECTIVE ON 'ME/CFS'
I want to make a controversial and potentially unpopular proposal: that ME/CFS is not a discrete disease in any objective sense and that attempting to more rigorously define a 'pure' ME/CFS cohort is futile.
In Parts I to III, I set out what I suggest Read more [...]
(Marco digs into a controversial subject in this second of two blogs on Stiff Person Syndrome and ME/CFS - "Is the depression/anxiety present in Stiff Person Syndrome and, possibly by reflection, chronic fatigue syndrome (ME/CFS), a consequence of having a difficult disease or is it an inherent Read more [...]
(Marco's first two Neuroinflammatory blogs lead us into sensory gating and glutatmate excitoxoicity and now he dives into a rare neurological disorder called Stiff Person Syndrome (SPS) (sometimes misdiagnosed as Fibromyalgia) with factors (high glutamate levels, increased sensitivity to stimulation, Read more [...]
(In a second of four-part series of papers elucidating a neuro-inflammatory model of chronic fatigue syndrome, Marco examines a possibility that could explain many symptoms and issue not just in ME/CFS but in other neurological disorders. Learn more about Marco here - Cort).
Pt 1 of the Neuroinflammatory Read more [...]
Researchers used a broad brush when they focused on the most easily understood aspect of the disorder - fatigue. Now, in this bold and provocative blog, the first part of a four-part series called "A Neuroinflammatory Model of ME/CFS", guest blogger Marco proposes that other symptoms, none Read more [...]