Archive for Research

The Fatigue and Pain Producers: Could Glial Cells Be ‘It’ in Chronic Fatigue Syndrome and Fibromyalgia?

It became evident that glial activation was not merely just correlated with pain, but that it was critically involved in inducing pathological pain. Suddenly glial cells are turning up in spades in Chronic Fatigue Syndrome and Fibromyalgia.  The Japanese neuroinflammation study found widespread Read more [...]

Problems Standing? Studies Suggest Autoimmunity Causes Orthostatic Intolerance: Implications For Chronic Fatigue Syndrome

"In conclusion, these data support the addition of POTS to a growing number of cardiovascular entities with an autoimmune pathophysiology." Authors The Rituximab findings, the female predominance, the increasing evidence of heritability, the inflammatory component, and the common infectious trigger Read more [...]

Neuroinflammation: Putting the ‘itis’ back into Myalgic Encephalomyelitis – Back to the Future For Chronic Fatigue Syndrome?

“Our results provide evidence of neuroinflammation in CFS/ME patients, as well as evidence of the possible contribution of neuroinflammation to the pathophysiology of CFS/ME.“ 'Show Me the Inflammation!' It’s perhaps emblematic of a complex and difficult to nail down illness such as ME/CFS Read more [...]

New Approach to Chronic Pain Leads to Novel Treatment Options: Antibiotics Anyone?

Pain Is Not All the Same Brain imaging studies like functional magnetic resonance imagery (FMRI) have provided tantalizing insights into the operation of the human brain. In this blog I’m going to review and highlight research and novel approaches by one of the leading researchers in the rapidly Read more [...]

Bacterial Resistance, Infection and Chronic Fatigue Syndrome: Fighting Infections Pt. I

This is the first of a second series of posts dealing with remission strategies from infections.  The contents will apply regardless of which infection model you believe causes Chronic Fatigue Syndrome. The usual models are: A bacterial infection in the body (tissue, bone marrow, blood) - for Read more [...]

EBV Back Front and Center: German Group Finds Immune Holes and Increased Levels of Epstein-Barr Virus in Chronic Fatigue Syndrome

Virtually everyone is exposed to Epstein-Barr Virus. If you catch it as a child you usually feel nothing, but if you're an adolescent you're likely to come down with infectious mononucleosis - and a greatly increased risk of ME/CFS. After German researchers noticed some strange EBV antibody Read more [...]

Sex, Autoimmunity and Chronic Fatigue Syndrome … or Why More Women Than Men Get ME/CFS

“Creating a scientific culture that compels consideration of sex in shaping the immune response is essential to a comprehensive understanding of health and disease.” The female predominance in autoimmune disorders (greater than 85% female in Sjogrens, lupus, Addison's disease, and scleroderma, Read more [...]

Shape Shifting Pain: How Chronic Pain Turns the Brain More ‘Emotional’

Recently we saw that some people appear to be sitting ducks for chronic pain.  Their brains have apparently reached a state, unbeknownst to them, where all that's needed for a chronic pain state to emerge is a triggering event such as an injury. That triggering even starts a process which changes Read more [...]