SENSORY GATING PART V – VALIDATION?
A - Sensory Gating Deficits and Neuroinflammation in ME/CFS – A Testable Hypothesis
Part I – Sensory Gating - Set out a hypothesis that, if tested, ME/CFS patients (in particular those patients that would describe themselves as the 'Wired and Tired' Read more [...]
(Exercise stress tests suggest a process that provides energy to the brain during exercise and intense mental activity may be broken and causing severe cognitive dysfunction in one group of GWS/ME/CFS patients (decreasers). A second GWS/ME/CFS group (increasers) with an intact brain lactate processing Read more [...]
(We're in the windup phase of Marco's Neuroinflammatory Series as he explores the role the immune system and pathogens play in producing the neuroinflammatory state that may underlie chronic fatigue syndrome (ME/CFS)
For more on Marco's Neuroinflammatory Series on ME/CFS
C - IMMUNE FINDINGS, Read more [...]
(Dr. Baraniuk finds damage to a critical nerve pathway that connects regions of the brain involved in fatigue and pain production and autonomic nervous system regulation. The damage, which affects the integrity of the nerve axons, is unusual and suggests GWS and perhaps ME/CFS are not related to Read more [...]
A – A PERSONAL PERSPECTIVE ON 'ME/CFS'
I want to make a controversial and potentially unpopular proposal: that ME/CFS is not a discrete disease in any objective sense and that attempting to more rigorously define a 'pure' ME/CFS cohort is futile.
In Parts I to III, I set out what I suggest Read more [...]
(Marco digs into a controversial subject in this second of two blogs on Stiff Person Syndrome and ME/CFS - "Is the depression/anxiety present in Stiff Person Syndrome and, possibly by reflection, chronic fatigue syndrome (ME/CFS), a consequence of having a difficult disease or is it an inherent Read more [...]
(Marco's first two Neuroinflammatory blogs lead us into sensory gating and glutatmate excitoxoicity and now he dives into a rare neurological disorder called Stiff Person Syndrome (SPS) (sometimes misdiagnosed as Fibromyalgia) with factors (high glutamate levels, increased sensitivity to stimulation, Read more [...]
Two million dollars for chronic fatigue syndrome (ME/CFS) research...You don't hear those words very often. The NIH just gave Dr. Shungu and associates a big two million dollar grant to peer into chronic fatigue syndrome patients brains.
This is the kind of study that makes you love the NIH; it's Read more [...]