Archive for GABA

Move over Lyrica and Cymbalta? Could Topamax (Topiramate) Be More Effective in Fibromyalgia?

"The present case highlights the marked improvement of FM symptoms in a patient who has been resistant to a wide variety of treatments for over seven years.“ Kararizou et. al. 2013 The Big Three (Lyrica, Cymbalta, Savella) Ghetto in Fibromyalgia Don’t get stuck in a rut when your doctor only Read more [...]

Cooling the Flames: Possible Approaches to Reducing Neuroinflammation in Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia

RESEARCH AVENUES/POTENTIAL TREATMENTS (Please note I have no medical background am in no way qualified to recommend any particular course of treatment for ME/CFS.  The following is a theoretical discussion that logically flows from the proposed neuroinflammatory hypothesis and is intended to outline Read more [...]

From Mood Disorders to MCS: A Neuroinflammatory Model Takes on the Symptoms in Chronic Fatigue Syndrome (ME/CFS)

 NEUROINFLAMMATORY MODEL OF ME/CFS Part IV – SYMPTOMS, HETEROGENEITY AND ONSET -PULLING IT ALL TOGETHER? B - CAN THE NEUROINFLAMMATORY STATE EXPLAIN THE CARDINAL SYMPTOMS OF ME/CFS? - SYMPTOMS - FROM MOOD DISORDERS TO TINNITUS Firstly, it must be acknowledged that this line of inquiry started Read more [...]

When Definitions Obscure: A Neuroinflammatory View of Chronic Fatigue Syndrome Pt. IV

A – A PERSONAL PERSPECTIVE ON 'ME/CFS'  I want to make a controversial and potentially unpopular proposal: that ME/CFS is not a discrete disease in any objective sense and that attempting to more rigorously define a 'pure' ME/CFS cohort is futile.   In Parts I to III, I set out what I suggest Read more [...]

Does A Rare Neurological Disorder Provide Clues to ME/CFS and FM? The Neuroinflammation Series Pt 3a

(Marco's first two Neuroinflammatory blogs lead us into sensory gating and glutatmate excitoxoicity and now he dives into a rare neurological disorder called Stiff Person Syndrome (SPS) (sometimes misdiagnosed as Fibromyalgia) with factors (high glutamate levels,  increased sensitivity to stimulation, Read more [...]