“the present findings offer clinical implications that may serve to guide future studies of the pathophysiology and management of a variety of persistent pain conditions.” Loggia et. al.
Chronic pain was thought for many years to be mostly a neuronal problem. Over or underactive neurons in the Read more [...]
Stanford did it right. They produced video's of the March 2014 Stanford Symposium on ME/CFS and now they're giving us access to them - for free. Some of the most exciting findings in years came out in the Symposium.
Dr. Unger's excellent introduction to epidemiology in Read more [...]
Minocycline: far beyond an antibiotic. N Garrido-Mesa, A Zarzuelo and J Gálvez. British Journal of Pharmacology (2013) 169 337–352 337 DOI:10.1111/bph.12139.
Tetracyclines and Neuromuscular Disorders. Daniele Orsucci1,*, Michelangelo Mancuso, Massimiliano Filosto and Gabriele Siciliano. Current Read more [...]
The microglia surround and protect the neurons in our brains and spinal cord. As the main immune defenders in the brain, they spew out an array of inflammatory and neurotoxic substances when activated. When we have a cold these substances cause the symptoms associated with ‘sickness behavior’ Read more [...]
"Pregabalin, duloxetine, milnacipran, and amitriptyline are the current first-line prescribed agents but have had a mostly modest effect. With only a minority of patients expected to experience substantial benefit, most will discontinue therapy because of either a lack of efficacy or tolerability problems." Read more [...]
It became evident that glial activation was not merely just correlated with pain, but that it was critically involved in inducing pathological pain.
Suddenly glial cells are turning up in spades in Chronic Fatigue Syndrome and Fibromyalgia. The Japanese neuroinflammation study found widespread Read more [...]