Ketamine and Fibromyalgia

Ketamines anesthetic properties appears to reduce the central nervous system excitability in Fibromyalgia

Ketamines anesthetic properties appears to reduce the central nervous system excitability in Fibromyalgia


Ketamine Is…..

an NMDA receptor antagonist that is usually used in anesthesia in humans and animals.  Often  delivered as an infusion or intramuscularly, or as a cream or gel (often in combination with other analgesics), Ketamine is effective, at least in the short term, in treating several chronic pain states including complex regional pain syndrome and fibromyalgia as well as difficult to treat cases of depression.

Ketamine might work in Fibromyaglia or Chronic Fatigue Syndrome (ME/CFS) Because…

It appears to reduce the central nervous system sensitization associated with increased pain in both disorders. An NMDA receptor inhibitor Ketamine also appears to reduce the activity of glutamate, the main excitatory neurotransmitter in the brain.  Glutamate excitotoxicity has been linked to fibromyalgia, depression, multiple sclerosis and possibly chronic fatigue syndrome (ME/CFS). Ketamine’s ability to enhance circulatory functioning is intriguing given the low blood volume and other possible circulatory issues in ME/CFS.

Chronic Fatigue Syndrome (ME/CFS) and Fibromyaglia Studies

No studies have examined Ketamine’s effectiveness in ME/CFS but several studies have examined it’s effectiveness in Fibromyalgia.  Given the need for infusions and Ketamine’s short-lived effects Ketamine may, however, be more important for what it tells researchers about Fibromyalgia than as an actual treatment aid.

Dutch researchers recently found  30-minute Ketamine infusions reduced pain levels in fibromyalgia by 50% but the effect was too short-lived, lasting less than 2 hours, to justify more treatment.  In a 2007 French study subcutaneous Ketamine reduced pain levels and increased blood flows in parts of the brain associated with pain regulation in Fibromyalgia patients.  An associated study suggested that a negative response to Ketamine in Fibromyalgia was associated with an inability to increase blood flows to the medial frontal gyrus. These areas of the brain appear to be important in producing pain in FM patients. (Ketamine increases heart rate and blood pressure).

A successful 2000 Danish study able to reduce both local and referred pain suggested Ketamine was reducing central nervous system ‘hyperexcitability’.  In a 2006 review article Wood suggested the positive response to Ketamine in fibromyalgia was not due to NMDA receptor inhibition but to increasing dopamine levels in limbic system neurons.

Ramachandran proposed  Ketamine’s anesthetic properties might be helpful in ‘dissociative disorders’ such as Fibromyalgia where patients attempt to dissociate themselves from their pain. Ketamine is known to create states of ‘dissociative anesthesia’ and, not surprisingly, has been used a recreational drug.

Chronic Fatigue Syndrome (ME/CFS) and Fibromyaglia Doctors Report

Dr. Podell reports that Ketamine reduces pain in about 50% of his fibromyalgia patients.  Ketamine was a key component of Dr. Jay Goldstein’s (now retired) “resurrection cocktail‘. Goldstein administered Ketamine intravenously or through a gel. The resurrection cocktail often included ascorbate, lidocaine and thyrotropin-releasing hormone. One report stated that 50% of Goldstein’s patients felt dramatically better after the cocktail.


Ketamine works in a large subset of Fibromyalgia patients but its expense, the need for infusions and its short-lived effects have blunted its use in that disorder. Some people travel out of the country to get less expensive ketamine infusions.

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